WebAlthough M2e-based vaccines are associated with weaker protection than HA-based vaccines that induce neutralizing antibodies against challenge virus matched-strain, the extracellular domain of Matrix 2 protein (M2e) is one of a potential broad-spectrum immunogen because it contains highly conserved sequences among influenza A viruses. WebAlthough M2e-based vaccines are associated with weaker protection than HA-based vaccines that induce neutralizing antibodies against challenge virus matched-strain, the …
M2e‐specific antibodies protect against influenza PR8 virus in an ...
WebImportance: M2e of influenza A is under investigation as a universal influenza A vaccine, but its three-dimensional structure is unknown. We describe the structure of M2e stabilized with an M2e-specific monoclonal antibody that recognizes natural M2. We found that the conserved tryptophan is positioned in the center of the U-shaped structure of M2e and … WebApr 14, 2024 · The ectodomain of influenza matrix protein 2 (M2e) is a promising target for the development of universal prophylactic and therapeutic agents against influenza viruses of different subtypes. We constructed three M2e-specific monoclonal antibody variants, M2A1-1 (IgG1), M2A1-2a (IgG2a), M2A1-2b (IgG2b), which have the same Fab region … linfield college wine studies
Frontiers Production of H5N1 Influenza Virus Matrix Protein 2 ...
WebFeb 13, 2015 · M2e is a highly conserved target for universal influenza A vaccine development. Different types of M2e-based vaccine, such as DNA vaccine, protein … WebA M2e-like approach, based on the conserved ectodomain of NB or BM2, might also provide protection against multiple influenza B strains, and so it should be explored further. The influenza A M2e and the conserved influenza B target epitope could be integrated into the same fusion construct or could be delivered as separate vaccine antigens. WebThe Matrix-2 (M2) protein is a proton-selective viroporin, integral in the viral envelope of the influenza A virus. The channel itself is a homotetramer (consists of four identical M2 units), where the units are helices stabilized … hot tub lines to low and getting water i them