WebHere, we show that in CD2-GATA3 transgenic mice, with enforced GATA3 expression driven by the CD2 promoter, thymocytes have reduced levels of CD5, which is a negative regulator of TCR signaling participating in TCR repertoire fine-tuning.

Erythroid Differentiation Regulator 1 Strengthens TCR Signaling …

WebJun 1, 2001 · This is consistent with reports linking increased CD5 expression with the strength of T cell receptor signalling and function: a possible strategy to fine-tune TCR … WebJun 1, 2011 · T-cells, by altering the expression levels of CD5, tune the threshold of TCR response. The level of CD5 expression is directly proportional to the avidity of antigen-specific receptors on T-cells and plays a crucial role during T-cell development [10] (Figure 2 a).B-cells can also modulate CD5 expression levels by a mechanism that involves the … data plane vs control plane

Biomedicines Free Full-Text CD5 Deficiency Alters Helper T Cell ...

WebAbstract: The CD5 transmembrane glycoprotein functions as a co-receptor in the signaling pathway linking T-cell antigen receptor (TCR) engagement to activation and differentiation. Although CD5 effects on TCR signaling have been shown to be primarily inhibitory, the underlying mechanisms remain unclear. WebMay 1, 2001 · The results demonstrate that inducible regulation of CD5 surface expression during thymocyte selection functions to fine tune the TCR signaling … WebMay 1, 2001 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J data plane in sdn